Definition of «promoter region»

The promoter region is a specific DNA sequence found in front of a gene, which plays an important role in regulating its expression. It serves as a binding site for RNA polymerase and other transcription factors that initiate the process of transcribing the gene into messenger RNA (mRNA). The promoter region determines where and when a gene is expressed by specifying the conditions under which it will be transcribed, such as cell type or developmental stage.

Sentences with «promoter region»

  • We searched for over-representation of DNA binding motifs in promoter regions of the 197 differentially expressed genes presented in Supplementary Table 3 using Pscan (28) and the JASPAR database (29). (diabetes.diabetesjournals.org)
  • While they spotted mutations in promoter regions in the genomes of pancreatic cancer cells, «these mutations weren't near any of the genes that prior research had already told us were typically mutated in pancreatic cancer,» says Michael Feigin, Ph.D., a postdoctoral researcher who led the work in the lab of CSHL Professor David Tuveson, M.D., Ph.D.. (cshl.edu)
  • Early life adversity and serotonin transporter gene variation interact to affect DNA methylation of the corticotropin - releasing factor gene promoter region in the adult rat brain (cambridge.org)
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